First TB vaccine booster unveiled by Seattle scientists
So far, the new vaccine has been tested only in laboratory animals. But if results are similar in people, it could prove a powerful tool to reduce the toll of a disease that kills nearly 2 million people a year — most of them in poor countries.
“The thing that got me excited is that this is the first example I know of where a boost strategy really made a substantial difference in outcome,” said David Sherman, a tuberculosis expert at Seattle BioMed who was not involved in the project.
The new vaccine was developed at the Infectious Disease Research Institute, a nonprofit bioscience laboratory.
Researchers hope to begin human trials early next year, said Steven Reed, IDRI founder and research director. If the vaccine’s effectiveness is borne out, he estimates it would be five to 10 years before it reaches the market.
The existing tuberculosis vaccine, called BCG (bacillus Calmette-Guerin), isn’t well known in the United States. But 120 million infants a year get the shot in Africa and much of the developing world. It provides partial protection against a virulent form of the disease, but the immunity wears off around the age of 10.
Scientists have been searching decades for a way to boost the vaccine.
The IDRI vaccine was able to confer lifelong immunity to guinea pigs that had received a BCG shot, Reed said.
“The real hope we have now is that we know immunity to tuberculosis can be enhanced over that provided by BCG, and it can be enhanced with an approach that is highly scalable, inexpensive and safe.”
The IDRI vaccine contains four key proteins from the bacterium that causes tuberculosis.
In mice, the vaccine protected against several strains of TB — including a strain that is resistant to drugs used to treat the disease. The vaccine also induced an immune response in monkeys and pigs.
Even if it proves equally effective in humans, the new vaccine is unlikely to replace BCG as a stand-alone shot, Sherman said. “Something would have to be dramatically better before the public health infrastructure all over the world changes what it does.”
But as a booster shot, the new vaccine might be able to protect people well into adulthood.
Tuberculosis can be treated, but the regimen includes multiple drugs and takes six months. Drug-resistant strains of the disease are becoming more common, including some that defy every weapon in the modern arsenal. With nearly a third of the world’s population harboring latent or active tuberculosis infections, the disease can also spread rapidly as people travel.
“If we think about making a dramatic reduction in tuberculosis death and transmission, a vaccine will be a very important component,” Reed said.
The research was funded by grants from the National Institutes of Health.
As a nonprofit, IDRI’s goal would be to license the vaccine to a manufacturer, probably in India, that would produce it at low cost and get it into the hands of those who need it.
First TB vaccine booster unveiled by Seattle scientists
Tags: laboratory animals, Health Medical Pharma, united states, guinea pigs
I will be subscribing to your feeds and even I achievement you access consistently fast.
Hi, the whole thing is going nicely here and ofcourse every one is sharing facts, that’s actually good, keep up writing.
Hi there, You have done a fantastic job. I’ll certainly digg it and personally suggest to my friends. I am confident they will be benefited from this website.
I like what you guys are up also. Such intelligent work and reporting! Keep up the superb works guys I have incorporated you guys to my blogroll. I think it’ll improve the value of my web site
Hey there! Wonderful stuff, please inform us when you publish again something similar!
Unquestionably believe that which you stated. Your favorite justification seemed to be on the web the easiest thing to be aware of. I say to you, I definitely get irked while people consider worries that they just do not know about. You managed to hit the nail upon the top and also defined out the whole thing without having side effect , people could take a signal. Will likely be back to get more. Thanks
Good website friend! I truly love how it is easy on my eyes it is. I\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\’m wondering how I might be notified whenever a new post has been made. I\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\’ve subscribed to your feed which may do the trick? Have a nice day!
Compelling article, great task. Your idea couldn’t have most certainly been drafted much better. Looking over this post strikes a chord in my memory about my previous boss! He commonly kept babbling relating to this. I most certainly will email this information to him. Entirely certain he will probably have a good read. Appreciate your writing about this!
Nice blog site here! Also your site loads up fast! What host are you using? Can I get your affiliate link to your host? (send it please to Papke@gmail.com) I wish my web site loaded up as quickly as yours lol… Office Management Jobs
Spot on with this write-up, I truly think this website needs much more consideration. I’ll probably be again to read much more, thanks for that info.
Let us not forget that Reagan’s future vp (Bush) and cia chief (Casey) met with the Ayatolla Khomeini behind the back of the then-current Carter administration (treason) and arranged for Iran to keep the American hostages until after the election. In return Iran got, at the very least, a conduit thru which to illegally receive missiles and other armaments–which came to light when traitor Ollie North got busted taking the missile $$$ and giving it to friends in Central America who turned out, naturally enough, to be drug smugglers USA-bound. Ah, the good old days…
I have realized that online degree is getting well-liked because getting your college degree online has changed into a popular method for many people. A lot of people have not necessarily had a possible opportunity to attend a conventional college or university however seek the raised earning possibilities and a better job that a Bachelor’s Degree offers. Still other people might have a qualification in one discipline but would wish to pursue anything they now develop an interest in.
You have to waste less time to look for your necessary topic on web, as today the searching strategies of search engines are pleasant. That’s why I fount this post at this place.
Good day very cool web site!! Man .. Excellent .. Wonderful .. I’ll bookmark your web site and take the feeds also…I’m happy to find a lot of helpful info right here in the submit, we need work out more techniques in this regard, thanks for sharing. . . . . .
Hi there, I found your website via Google while looking for a related topic, your web site came up, it looks good. I’ve bookmarked it in my google bookmarks.
One thing that you can do to help you save money is to find cheap (reely) packing materials. You may also be able to come across a place that will give their boxes away after they happen to be used. Buying boxes or containers yourself can be very costly, however, you can help to save money by checking with the employees at your local supermarket to ascertain if they will give you some of their boxes for free.
How many followers can be of your blog at blogspot?
The web page am nice, I realized of a plenty of excellent achievements. I like the strategy that you design your web websites. Continue the outstanding function and could you might get fantastic outcomes within the long run.
hello!,I like your writing very much! share we communicate more about your post on AOL? I need a specialist on this area to solve my problem. Maybe that’s you! Looking forward to see you.
some really prime content on this internet site , saved to fav.
You have definitely made some great points thoughout the article and I can definitely agree with you on almost everything you said. I will be returning very soon.
We’ve scan the internet a great deal additional than a couple of a number of hours right now, and your weblog internet site was the great coming from all. Thank you; it can be really valuable to us.
This is the right blog for anyone who wants to find out about this topic. You realize so much its almost hard to argue with you (not that I actually would want…HaHa). You definitely put a new spin on a topic thats been written about for years. Great stuff, just great!
Unquestionably believe that which you stated. Your favorite justification seemed to be on the web the easiest thing to be aware of. I say to you, I definitely get irked while people consider worries that they just do not know about. You managed to hit the nail upon the top and also defined out the whole thing without having side effect , people could take a signal. Will likely be back to get more. Thanks
Najlepsze biuro rachunkowe w Mysłowicach. taxcom.pl to przede wszystkim faktury, rozliczeina u usługi księgowe.
Hi my friend! I want to say that this post is amazing, nice written and include approximately all important infos. I’d like to see more posts like this .
Its like you read my mind! You seem to know so much about this, like you wrote the book in it or something. I think that you could do with a few pics to drive the message home a bit, but instead of that, this is wonderful blog. An excellent read. I’ll certainly be back.
I am extremely impressed with your writing skills and also with the layout on your blog. Is this a paid theme or did you modify it yourself? Anyway keep up the nice quality writing, it’s rare to see a nice blog like this one these days..
A person essentially help to make seriously posts I would state. This is the first time I frequented your website page and thus far? I amazed with the research you made to make this particular publish extraordinary. Wonderful job!
I will right away clutch your rss as I can not find your e-mail subscription link or e-newsletter service. Do you have any? Kindly allow me understand so that I could subscribe. Thanks.
Stackable boxes really are a must when moving house, irrespective of self-drive van hire or removal company lorry. Sturdy green, recyclable boxes that may be reused repeatedly are the most useful choice for frequent house moves and for long-term storage – regardless of where the home move takes place. There’s nothing more frustrating than having to reload many times, because the awkward manner in which things are packed prevent a fully loaded van making one tour and something tour only.
I was recommended this blog by my cousin. I am not sure whether this post is written by him as nobody else know such detailed about my problem. You’re wonderful! Thanks!
Hello there, You have done an incredible job. I will certainly digg it and personally recommend to my friends. I’m confident they’ll be benefited from this web site.
Perhaps you’ve thought-about having supplementary clips in your posts to hold the readers much more interested? What i’m saying is I just read over the write-up of yours and this appears to be totally interesting but since I?m a lot more like a visual learner, I have found video recordings extremely helpful. Better inform me the actual way it ends up! I’m a sucker for everything you people are often up to. Such a bright work as well as reporting! Keep up the extraordinary work fellas. I?ve went ahead and added you guys to my own blogroll. This is actually a great posting and thanks for posting about it this kind of useful content. I’m going to visit your wordpress bog routinely for most recent stuff
Photos usually are an integral part of any wedding ceremony. Couples are generally happy to acquire their images again on the photographer for them to relive his or her special day. Although there are lots of unique routines it is possible to create right into a wedding party which entail photos.One particular fun undeniable fact that so many women utilize is usually to get photographs of everybody since they get through the wedding, almost like you choose to do at the high school prom or even corporation Xmas party. You possibly can give you a backcloth in addition to partners can cause because of a new paid for lensman and anyone goes wrong with pick up you.
Thanks for the article on this subject, I found it to be very interesting and informative, hope to view more from your blog soon.
Can I just say what a reduction to search out someone who really knows what theyre speaking about on the internet. You positively know the best way to bring a problem to light and make it important. Extra folks have to read this and perceive this facet of the story. I cant believe youre not more common since you positively have the gift.
Whats Going down i am new to this, I stumbled upon this I have discovered It absolutely helpful and it has helped me out loads. Micro needle rollerI am hoping to give a contribution & help other customers like its aided me. Great job.
I want to convey my love for your generosity supporting persons who really need help on that study. Your special dedication to getting the solution all over appeared to be pretty significant and has usually allowed ladies much like me to realize their endeavors. Your entire interesting tutorial denotes a whole lot to me and much more to my mates. Warm regards; from each one of us.
Whats up very nice site!! Guy .. Excellent .. Amazing .. I will bookmark your website and take the feeds additionally…I am glad to seek out so many useful information right here within the submit, we want work out more strategies on this regard, thanks for sharing. . . . . .
It’s excellent webpage, I was looking for something like this
It’s excellent page, I was looking for something like this
Your place is valueble for me. Thanks!…
Some truly superb info , Gladiola I noticed this.
great site with lots of information on used cars you should really check it out
The other reason why moving house in Germany could be much will that obtaining free cardboard boxes is virtually impossible. One cannot go to a local supermarket or newsagent to inquire about discarded boxes. Everything in Germany is being recycled – a cardboard box that once held cans of pet food or washing powder is invariably coming with a recycling plant before one has a chance to ask. Most German removal firms offer therefore green, recyclable boxes either for sale or for hire – at a high price.
I have to get across my passion for your kindness giving support to individuals that actually need help with that niche. Your personal dedication to getting the solution all over appears to be extremely beneficial and has really empowered regular people like me to achieve their ambitions. Your entire useful facts indicates a great deal to me and much more to my fellow workers. Many thanks; from all of us.
It is very effective article. It is well written and has fun. Also, it is very informative. http://reward4work.com/
Enjoyed reading through this, very good stuff, thankyou .
Let us not forget that Reagan’s future vp (Bush) and cia chief (Casey) met with the Ayatolla Khomeini behind the back of the then-current Carter administration (treason) and arranged for Iran to keep the American hostages until after the election. In return Iran got, at the very least, a conduit thru which to illegally receive missiles and other armaments–which came to light when traitor Ollie North got busted taking the missile $$$ and giving it to friends in Central America who turned out, naturally enough, to be drug smugglers USA-bound. Ah, the good old days…